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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AB2P
All Species:
12.42
Human Site:
S183
Identified Species:
21.03
UniProt:
Q58FF8
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q58FF8
NP_031381
381
44349
S183
G
S
D
E
E
D
D
S
G
K
D
K
K
K
K
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
K270
S
D
E
E
E
E
E
K
K
D
G
D
K
K
K
Rhesus Macaque
Macaca mulatta
XP_001098219
597
68451
R280
A
L
L
F
I
P
R
R
A
P
F
D
L
F
E
Dog
Lupus familis
XP_857093
509
59005
K195
S
D
E
E
E
E
E
K
K
D
G
D
K
K
K
Cat
Felis silvestris
Mouse
Mus musculus
P11499
724
83307
S261
G
S
D
E
E
D
D
S
G
K
D
K
K
K
K
Rat
Rattus norvegicus
P34058
724
83263
S261
G
S
D
E
E
D
D
S
G
K
D
K
K
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518700
789
90657
G353
G
S
D
E
E
D
E
G
G
K
D
K
K
K
K
Chicken
Gallus gallus
Q04619
725
83409
G262
S
D
E
E
E
E
E
G
E
K
S
K
K
K
K
Frog
Xenopus laevis
NP_001086624
722
82939
E259
V
G
S
D
E
E
E
E
G
K
D
K
K
K
K
Zebra Danio
Brachydanio rerio
O57521
725
83339
T260
G
S
D
D
E
E
D
T
K
D
K
D
K
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
K254
G
E
D
E
D
A
D
K
K
D
K
D
A
K
K
Honey Bee
Apis mellifera
XP_395168
718
82735
E257
D
E
N
E
E
A
P
E
E
E
G
K
K
K
K
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
A240
E
G
E
V
E
N
V
A
D
D
A
D
K
K
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51818
699
80034
E240
K
V
E
E
V
D
E
E
K
E
K
E
E
K
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
41.6
51.4
58.7
N.A.
47.2
47.5
N.A.
42.4
44.8
45
43.7
N.A.
38.4
38.1
36.1
N.A.
Protein Similarity:
100
47.3
55.7
67.5
N.A.
49.8
50
N.A.
45.2
48.5
48.4
48.6
N.A.
45.1
44.4
45.1
N.A.
P-Site Identity:
100
33.3
0
33.3
N.A.
100
100
N.A.
86.6
46.6
53.3
53.3
N.A.
40
40
26.6
N.A.
P-Site Similarity:
100
53.3
6.6
53.3
N.A.
100
100
N.A.
93.3
66.6
73.3
73.3
N.A.
46.6
53.3
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
34
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
43.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
15
0
8
8
0
8
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
22
43
15
8
36
36
0
8
36
36
43
0
0
0
% D
% Glu:
8
15
36
72
79
36
43
22
15
15
0
8
8
0
8
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
8
0
0
8
0
% F
% Gly:
43
15
0
0
0
0
0
15
36
0
22
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
0
22
36
43
22
50
79
93
93
% K
% Leu:
0
8
8
0
0
0
0
0
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
8
8
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% R
% Ser:
22
36
8
0
0
0
0
22
0
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
8
8
0
8
8
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _